Highlights
Alexandre Caron, Ryan P. Reynolds, Carlos M. Castorena, Natalie J. Michael, Charlotte E. Lee, Syann Lee, Rebecca Berdeaux, Philipp E. Scherer, Joel K. Elmquist. (2019) Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis. https://doi.org/10.1016/j.molmet.2019.06.019.
Akhmedov D, Kirkby N, Mitchell J, Berdeaux R. (2019) Imaging of Tissue-Specific and Temporal Activation of GPCR Signaling Using DREADD Knock-In Mice. G Protein-Coupled Receptor Signaling pp 361-376.
Lei Wang, Sai P. Pydi, Yinghong Cui, Lu Zhu, Jaroslawna Meister, Oksana Gavrilova, Rebecca Berdeaux, Jean-Philippe Fortin, Kendra K. Bence, Cecile Vernochet, Jürgen Wess. (2019)
Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice. https://doi.org/10.1016/j.molmet.2019.06.018.
Baharan Fekry , Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun1, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek & Kristin Eckel-Mahan. (2018) Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195513/.
Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, Rivera-Molina M, Gibson M, Berglund ED, Justice NJ and Berdeaux R. (2016) Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity. Molecular Metabolism, 5(1): 34-46.
Kim, E.R., Fan, S., Akhmedov, D., Sun, K., Lim, H., O’Brien, W., Xu, Y., Mangieri, L.R., Zhu, Y., Lee, C.C., Chung, Y., Xia, Y., Xu, Y., Li, F., Sun, K., Berdeaux, R., and Tong, Q. (2017) Red blood cell b-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply. JCI Insight. 2(14): e93367.
Akhmedov D, Mendoza-Rodriguez MG, Rajendran K, Rossi M, Wess J and Berdeaux R. (2017) Gs-DREADD knock-in mice for tissue-specific, temporal stimulation of cyclic AMP signaling. Mol. Cell. Biol., 37(9): e00584-16.
Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, and Berdeaux R. (2016) Knock-in luciferase reporter mice for in vivo monitoring of CREB activity. PLoS ONE, 11(6): e0158274.
Akhmedov D, Kirkby N, Mitchell J, Berdeaux R. (2019) Imaging of Tissue-Specific and Temporal Activation of GPCR Signaling Using DREADD Knock-In Mice. G Protein-Coupled Receptor Signaling pp 361-376.
Lei Wang, Sai P. Pydi, Yinghong Cui, Lu Zhu, Jaroslawna Meister, Oksana Gavrilova, Rebecca Berdeaux, Jean-Philippe Fortin, Kendra K. Bence, Cecile Vernochet, Jürgen Wess. (2019)
Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice. https://doi.org/10.1016/j.molmet.2019.06.018.
Baharan Fekry , Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun1, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek & Kristin Eckel-Mahan. (2018) Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195513/.
Nixon M, Stewart-Fitzgibbon R, Fu J, Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, Rivera-Molina M, Gibson M, Berglund ED, Justice NJ and Berdeaux R. (2016) Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity. Molecular Metabolism, 5(1): 34-46.
Kim, E.R., Fan, S., Akhmedov, D., Sun, K., Lim, H., O’Brien, W., Xu, Y., Mangieri, L.R., Zhu, Y., Lee, C.C., Chung, Y., Xia, Y., Xu, Y., Li, F., Sun, K., Berdeaux, R., and Tong, Q. (2017) Red blood cell b-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply. JCI Insight. 2(14): e93367.
Akhmedov D, Mendoza-Rodriguez MG, Rajendran K, Rossi M, Wess J and Berdeaux R. (2017) Gs-DREADD knock-in mice for tissue-specific, temporal stimulation of cyclic AMP signaling. Mol. Cell. Biol., 37(9): e00584-16.
Akhmedov D, Rajendran K, Mendoza-Rodriguez MG, and Berdeaux R. (2016) Knock-in luciferase reporter mice for in vivo monitoring of CREB activity. PLoS ONE, 11(6): e0158274.
All Publications
Valera, J.M., Diaz, T., Petty, L.E., Quintans, B., Yanez, Z., Boerwinkle, E., Muzny, D., Akhmedov, D., Berdeaux, R., Sobrido, M.J., Lupski, J.R., Geschwind, D.H., Perlman, S., Below J.E., and Fogel, B.L. (2017) Prevalence of spinocerebellar ataxia 36 in a US population. Neurol. Genet., 3(4): e174.
Wong, C.O., Palmieri, M., Li, J., Akhmedov, D., Chao, Y., Broadhead, G., Zhu, M.X., Berdeaux, R., Collins, C., Sardiello, M. and Venkatachalam, K. (2015) Diminished mTORC2-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction. Cell Reports, 12(12): 2009-2020.
Akhmedov, D., Berdeaux, R. (2014) The effects of obesity on muscle regeneration. Frontiers in Physiology: Striated Muscle Physiology, 4: 371.
Zuo, Y., Berdeaux, R. and Frost, J. The RhoGEF Net1 is required for normal mammary gland development. (2014) Molecular Endocrinology 28(12): 1948-60.
Fu, J., Akhmedov, D., and Berdeaux, R. The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes. (2013) PLoS ONE, 8(10): e78522.
Clark, R.I., Tan, S.W.S., Péan, C., Roostalu, U., Vivancos, V., Bronda, K., Pilátová, M., Fu, J., Walker, D.W., Berdeaux, R., Geissmann, F., and Dionne M.S. (2013) Mef2 is an in vivo immune-metabolic switch. Cell, 155(2): 455-447.
Chatterjee, S., Nam, D., Guo, B., Kim, J.M., Wennier, G.E., Lee, J., Berdeaux, R., Yechoor, V.K. and Ma, K. (2013) Brain and Muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci., 126 (Pt 10): 2213-24.
Stewart, R.*, Akhmedov, D.*, Robb, C., Leiter, C., Berdeaux, R. Regulation of SIK1 abundance and stability is critical for myogenesis. (2013) PNAS, 110(1): 117-22. (*Equal contribution)
Berdeaux, R., Stewart, R. (2012) cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism and regeneration. Am J Physiol: Endo and Metab. 303(1): E1-17. (Cover illustration)
Luo, J., Stewart, R., Berdeaux, R., Hu, H. (2012) Tonic inhibition of TRPV3 by Mg2+ in mouse epidermal keratinocytes. J Invest Dermatol. 132(9): 2158-65.
Stewart, R., Flechner, L., Montminy, M., Berdeaux, R. (2011) CREB is activated by muscle injury and promotes muscle regeneration. PloS ONE 6(9): e24714.
Berdeaux, R. (2011) Metabolic regulation by salt inducible kinases. Front Biol. 6(3): 231-241.
Song, Y., Altarejos, J., Goodarzi, M.O., Inoue, H., Guo, X., Berdeaux, R., Kim, J.H., Goode, J., Igata, M., Paz, J., Hogan, M.F., Singh, P., Goebel, N., Miller, N., Cui, J., Jones, M.R., Taylor, K.D., Hsueh, W.A., Rotter, J.I., Montminy, M. (2010) The CREB coactivator CRTC3 links catecholamine signaling to energy balance. Nature. 468(7326): 933-9.
Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G.D., Montminy, M. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 13(5): 597-603. (Cover illustration)
Zhu, Q., Krakowski, A.R., Dunham, E.E., Wang, L., Bandyopadhyay, A., Berdeaux, R., Martin, G.S., Sun, L., Luo, K. (2007) Dual Role of SnoN in Mammalian Tumorigenesis. Mol Cell Biol. 27(1): 324-39.
Leuchtenberger, S., Kummer, M.P., Kukar, T., Czirr, E., Teusch, N., Sagi, S.A., Berdeaux, R., Pietrzik, C.U., Ladd, T.B., Golde, T.E., Koo, E.H., Weggen, S. (2006) Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem. 96(2): 355-65.
Canettieri, G., Koo, S.H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., Montminy, M. (2005) Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab. 2(5): 331-8.
Berdeaux, R.L.*, Díaz, B.*, Kim, L.C., and Martin, G.S. (2004) Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J. Cell Biol. 166(3): 317-23. (*Equal contribution. Comment in J. Cell Biol. 166(3): 305.)
Hofer, F., Berdeaux, R., and Martin, G.S. (1998) Ras-independent activation of Ral by a Ca(2+)-dependent pathway. Curr Biol. 8(14): 839-42.
Schelman, W.R., Kurth, J.L., Berdeaux, R.L., Norby, S.W., Weyhenmeyer, J.A. (1997) Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signaling in neuronal cells. Brain Res Mol Brain Res. 48(2): 197-205.
Wong, C.O., Palmieri, M., Li, J., Akhmedov, D., Chao, Y., Broadhead, G., Zhu, M.X., Berdeaux, R., Collins, C., Sardiello, M. and Venkatachalam, K. (2015) Diminished mTORC2-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction. Cell Reports, 12(12): 2009-2020.
Akhmedov, D., Berdeaux, R. (2014) The effects of obesity on muscle regeneration. Frontiers in Physiology: Striated Muscle Physiology, 4: 371.
Zuo, Y., Berdeaux, R. and Frost, J. The RhoGEF Net1 is required for normal mammary gland development. (2014) Molecular Endocrinology 28(12): 1948-60.
Fu, J., Akhmedov, D., and Berdeaux, R. The short isoform of the ubiquitin ligase NEDD4L is a CREB target gene in hepatocytes. (2013) PLoS ONE, 8(10): e78522.
Clark, R.I., Tan, S.W.S., Péan, C., Roostalu, U., Vivancos, V., Bronda, K., Pilátová, M., Fu, J., Walker, D.W., Berdeaux, R., Geissmann, F., and Dionne M.S. (2013) Mef2 is an in vivo immune-metabolic switch. Cell, 155(2): 455-447.
Chatterjee, S., Nam, D., Guo, B., Kim, J.M., Wennier, G.E., Lee, J., Berdeaux, R., Yechoor, V.K. and Ma, K. (2013) Brain and Muscle Arnt-like 1 is a key regulator of myogenesis. J Cell Sci., 126 (Pt 10): 2213-24.
Stewart, R.*, Akhmedov, D.*, Robb, C., Leiter, C., Berdeaux, R. Regulation of SIK1 abundance and stability is critical for myogenesis. (2013) PNAS, 110(1): 117-22. (*Equal contribution)
Berdeaux, R., Stewart, R. (2012) cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism and regeneration. Am J Physiol: Endo and Metab. 303(1): E1-17. (Cover illustration)
Luo, J., Stewart, R., Berdeaux, R., Hu, H. (2012) Tonic inhibition of TRPV3 by Mg2+ in mouse epidermal keratinocytes. J Invest Dermatol. 132(9): 2158-65.
Stewart, R., Flechner, L., Montminy, M., Berdeaux, R. (2011) CREB is activated by muscle injury and promotes muscle regeneration. PloS ONE 6(9): e24714.
Berdeaux, R. (2011) Metabolic regulation by salt inducible kinases. Front Biol. 6(3): 231-241.
Song, Y., Altarejos, J., Goodarzi, M.O., Inoue, H., Guo, X., Berdeaux, R., Kim, J.H., Goode, J., Igata, M., Paz, J., Hogan, M.F., Singh, P., Goebel, N., Miller, N., Cui, J., Jones, M.R., Taylor, K.D., Hsueh, W.A., Rotter, J.I., Montminy, M. (2010) The CREB coactivator CRTC3 links catecholamine signaling to energy balance. Nature. 468(7326): 933-9.
Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G.D., Montminy, M. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med. 13(5): 597-603. (Cover illustration)
Zhu, Q., Krakowski, A.R., Dunham, E.E., Wang, L., Bandyopadhyay, A., Berdeaux, R., Martin, G.S., Sun, L., Luo, K. (2007) Dual Role of SnoN in Mammalian Tumorigenesis. Mol Cell Biol. 27(1): 324-39.
Leuchtenberger, S., Kummer, M.P., Kukar, T., Czirr, E., Teusch, N., Sagi, S.A., Berdeaux, R., Pietrzik, C.U., Ladd, T.B., Golde, T.E., Koo, E.H., Weggen, S. (2006) Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem. 96(2): 355-65.
Canettieri, G., Koo, S.H., Berdeaux, R., Heredia, J., Hedrick, S., Zhang, X., Montminy, M. (2005) Dual role of the coactivator TORC2 in modulating hepatic glucose output and insulin signaling. Cell Metab. 2(5): 331-8.
Berdeaux, R.L.*, Díaz, B.*, Kim, L.C., and Martin, G.S. (2004) Active Rho is localized to podosomes induced by oncogenic Src and is required for their assembly and function. J. Cell Biol. 166(3): 317-23. (*Equal contribution. Comment in J. Cell Biol. 166(3): 305.)
Hofer, F., Berdeaux, R., and Martin, G.S. (1998) Ras-independent activation of Ral by a Ca(2+)-dependent pathway. Curr Biol. 8(14): 839-42.
Schelman, W.R., Kurth, J.L., Berdeaux, R.L., Norby, S.W., Weyhenmeyer, J.A. (1997) Angiotensin II type-2 (AT2) receptor-mediated inhibition of NMDA receptor signaling in neuronal cells. Brain Res Mol Brain Res. 48(2): 197-205.