Anabolic and Pro-metabolic Functions of CREB-CRTC in Skeletal Muscle:
Advantages and Obstacles for Type 2 Diabetes and Cancer Cachexia
Berdeaux, R. and Hutchins, C. (2019) Frontiers in Endocrinology - Cellular Endocrinology. epub 8/2/2019
Part of the Research Topic "Connecting the Dots between Obesity, Diabetes and Cancer"
This mini-review describes the functions of the transcription factor CREB and its co-activators (CRTCs) in skeletal muscle metabolism and hypertrophy, with an emphasis on whether CREB/CRTCs could be viable therapeutic targets to sustain muscle mass and function in people wiht type 2 diabetes or cancer.
The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC |
Pablo E Hollstein, Lillian J Eichner, Sonja N Brun, Anwesh Kamireddy, Robert U Svensson, Liliana I Vera, Debbie S Ross, TJ Rymoff, Amanda Hutchins, Hector M Galvez, April E Williams, Maxim N Shokhirev, Robert A Screaton, Rebecca Berdeaux and Reuben J Shaw (2019) Cancer Discovery, Jul 26. pii: CD-18-1261.
This research paper lead by Reuben Shaw at The Salk Institute identifies key roles of AMPK-related kinases SIK1 and SIK3 in suppression of certain lung cancers. Read the Salk Institute press release!